We found that the top ranking TF, ZEB1, previously known for its role in epithelial to mesenchymal transition (EMT) and tumor metastasis (Vandewalle et al., 2009; Gheldof et al., 2012), is a critical mediator of in vitro and in vivo adipogenesis, as it directly controls the majority of aGRN genes. The gene discussed is ZEB1; the disease is neoplasm.