Among its dysregulated genes, CCND2 is differentially expressed between breast cancer patients with bone metastases and other patients [11]; E2F1 can regulate DZ13 to induce a cytotoxic stress response in tumour cells metastasizing to bone [39]; TGFB2 is related to the bone metastases development [40]. This evidence concerns the gene E2F1 and neoplasm.