MAPT and early-onset autosomal dominant Alzheimer disease: Indeed, experimental work suggests the presence in glaucoma of a neuronal alteration of the constitutive autophagy process, a molecular mechanism also present in Alzheimer disease and that could cause accumulation of misfolded proteins (e.g., β-amyloid and tau in Alzheimer disease) as well as templating and spreading of proteins across brain, ultimately leading to neural cell death [18].