TNF and neoplasm: Among these molecules, the pro-inflammatory cytokines IL1-beta, IL-6, IL-8, the vascular endothelial growth factor (VEGF) promoting tumor angiogenesis, the hepatocyte growth factor (HGF) which stimulates cell migration and tumor invasiveness, the transforming growth factor beta (TGF-β) implicated in tumor growth, the platelet-derived growth factor (PDGF) which regulates MM cells proliferation and the tumor necrosis factor alpha (TNF-α), have been found more frequently over-expressed in the microenvironment of mesothelial cells during neoplastic transformation [21], [23], [24].