PDLIM7 and B-cell chronic lymphocytic leukemia: Presently it is emphasized that subclonal variation and selection lead to the evolution of the disease with alteration of the biological behavior, activation state and proliferation of the cells.[9], [10], [11] In some cases EBV carrying subclones have been detected by their capacity to proliferate in vitro; giving rise to LCLs with proven CLL origin.[56], [57]In vitro infected CLL cells exhibit an unusual viral latency, Type IIb; the cells express EBNA-2 but not LMP-1 and they do not proliferate.