HIF1A and non-small cell lung carcinoma: To confirm the role of RBP2 in regulating HIF-1α in NSCLC cells, we modulated HIF-1α expression by transfecting cells with an siRNA specific against HIF-1α (si-HIF-1α) and a plasmid pcDNA3-HA-HIF-1α, and evaluated the expression of VEGF after 36 hours.