Immunohistochemistry with RBP2 (Fig. 1A and Fig. 1B) and HIF-1α (Fig. 1D and Fig. 1E) antibodies showed a positive reaction in the nucleus, and VEGF antibodies (Fig. 1F and Fig. 1G) showed a positive reaction in the cytoplasm of tumor cells. The gene discussed is RBP2; the disease is neoplasm.