None of the new chimeric mice showed accelerated tumorigenesis or higher incidence of tumors, yet 3 of 4 tumors harboring CDK14 or CDK14/CDK6/FZD1 were easily propagated, strongly suggesting that overexpression of CDK6 and CDK14 are important for ectopic tumor growth and metastasis. Here, FZD1 is linked to neoplasm.