MET and neoplasm: Immunohistochemical staining for HGF was positive in 70–80% of these tumor cells, and staining for phospho-MET revealed high MET expression and activation, but curiously no EGFR positivity (Fig. 3C–F and data not shown) as commonly seen in human CRC [18] and other primary tumors of the ES-chimera B-catenin colon model.