The present study also suggests that VEGFR1-expressing macrophages are derived from the BM, and that the recruitment of BM-derived VEGFR1- expressing macrophages to the injured livers after hepatic I/R is dependent of VEGFR1 signaling, which is consistent with our recent results in a model of murine gastric ulcer healing [18] and wound healing [13]. Here, FLT1 is linked to gastric ulcer.