The observed relationship between blood BDNF levels and brain activity illustrates the roleof blood BDNF in the healthy brain; however, the significantly different correlation betweenplasma BDNF levels and task-related neural activity in schizophrenia suggests that bloodBDNF may not be a suitable biomarker of functional or task-related activity inschizophrenia. This evidence concerns the gene BDNF and schizophrenia.