We here aimed to observe the effect of SOCS7 knockdown on the behaviour of breast cancer both in vitro and in vivo and to investigate whether SOCS7 knockdown in breast cancer cells MCF7 (ER +ve) and MDA-MB-231 (ER −ve) can affect their in vitro growth and migrational responses when treated with HGF. This evidence concerns the gene HGF and breast carcinoma.