Additionally, enlarged GFAP+ vascular end-feet, which typically highlight the wall of vessels in developing NDP (Figures 9(b), 10(b), and 10(c)), and increased amount of GFAP+ gliofilaments forming thick bundles within the cytoplasm of reactive astrocytes belong to significant features of concomitant astrogliosis in brain of both tgHD rats and HD patients. This evidence concerns the gene GFAP and Huntington disease.