Significant for those “reactive” astrocytes involved in NDP is also the absence of reexpression of other intermediate filaments, nestin and vimentin (abundantly expressed in immature astrocytes), whose adaptation is characteristic for immediate activation of astrocytes not only in case of the acute brain injury (e.g., the formation of the glial scar) but also in neurotoxic models of HD [64]. The gene discussed is VIM; the disease is Huntington disease.