Interestingly, in MYCN-amplified (without RB1 mutations) retinoblastoma (Rushlow et al. 2013) compared to RB1-mutated retinoblastomas, we found a significant downregulation of the core complex members: FANCA (FC = -3.99, P = 3.69E-03), FANCC (FC = -1.91, P = 1.46E-02), FANCL (FC = -2.56, P = 2.72E-06), FANCM (FC = -2.07, P = 2.16E-02); central player: FANCI (FC = -3.74, P = 1.56E-02); and downstream branch member BRCA1 (FC = -2.36, P = 8.85E-03; Additional file 2: Table S1) compared to classic retinoblastoma (with RB1 mutations). Here, RB1 is linked to retinoblastoma.