Notably, in experimental meningitis, PARP1-deficient mice and mice treated with the PARP inhibitor, 3 aminobenzamide (3-AB), display reduced leukocyte infiltration and meningeal inflammation, and this is correlated with impaired expression of Il1β, Il6 and Nos2 (Koedel et al. 2002). This evidence concerns the gene IL1B and meningitis.