However, a role for MBNL1 in FXTAS has been excluded, because no genetic interaction between MBNL1 and CGG-mediated neurodegeneration was observed in the fly model of FXTAS [59], and no misregulation of splicing events regulated by MBNL1 was observed in brain samples from patients with FXTAS [60]. This evidence concerns the gene MBNL1 and fragile X-associated tremor/ataxia syndrome.