A few years ago we [20–21] reported about the synthesis and inhibitory properties of a small library of lactosylthioureidocalixarenes and found that the cone derivatives I and III (Figure 1) were able to efficiently inhibit the adhesion of Gal-3 to tumor cells in vitro, but not that of galectin-1 [22]. The gene discussed is LGALS1; the disease is neoplasm.