In MOLF/Ei mice susceptibility to infection as explained by the Ity3 locus could be attributed to the individual effect of Ity3.1 and Ity3.2 sub-loci but also to the cooperation between these two sub-loci as explained by the potential impact of low activity of NADPH oxidase (16) on Selp function by reducing its expression (current paper). Here, FMO5 is linked to infection.