A large number of differentially expressed genes specific to Ity mice (Table S1F in Supplementary Material) were up-regulated in granulocytes and/or macrophages including S100a8 and S100a9 that are of particular interest as they are involved with expression of inflammatory mediators, phagocytosis, oxidative burst as well as migration of neutrophils and monocytes to the site of infection (23). The gene discussed is S100A8; the disease is infection.