APOE and Alzheimer disease: Of utmost importance for this review, children with the Apolipoprotein E allele 4 (a well-known risk factor for AD) had greater HPτ and diffuse Aβ plaques vs. E3 carriers, suggesting that genetic factors could make a significant portion of the exposed population more prone to accelerating their AD pathology (Calderón-Garcidueñas et al., 2012a).