ENPEP and Alzheimer disease: Supportive data demonstrated that APα functioned as a neurotrophic factor for human, rat, and mouse neural progenitor cells (Keller et al., 2004; Wang et al., 2005, 2010; Charalampopoulos et al., 2008) and augmented the number of cells in the hippocampus and reversed deficits in learning and memory in a mouse model for Alzheimer’s disease (3xTgAD, a triple transgenic with APPSwe, PS1M146V, tauP301L) (Wang et al., 2010; Chen et al., 2011; Singh et al., 2012), for review see Brinton (2013) and Irwin and Brinton (2014).