Yioti et al. [12] in a very recent study, evaluated the polymorphisms related to thrombophilia/hypofibrinolysis in a Greek population, and concluded that there might be an association between increased risk for RVO and ACE I/D, MTHFR C677T, PAI-1 4G/5G and factor V Leiden polymorphisms. The gene discussed is MTHFR; the disease is Rare hereditary thrombophilia.