Hypoxia after high intracranial venous pressure leads to the following pathophysiological changes: 1) HIF expression is increased and then VEGF is activated, 2) VEGF has the highest expression in the sinus surrounding the most severe ischemia, 3) a dural venous sinus is formed and dural neovascularization is observed to increase, 4) part of the neovascularization is connected with the original artery which results in arterial blood flowing directly into the sinus resulting in DAVF formation. The gene discussed is VEGFA; the disease is ischemia.