By querying recently reported gene sets [30,31] and high confidence driver genes [32], the melanoma sample analysis revealed that clonal gains over chromosome 8q, including the proto-oncogene MYC, precede a missense mutation of NF1, a negative regulator of RAS signaling [30], and that deletions on 6q spanning the pro-apoptotic factor BCLAF1 (Bcl2-associated factor 1) consistently precede missense mutations of NBPF10 (chromosome 1q21.1) and RANBP2 (chromosome 2q12.3). This evidence concerns the gene RANBP2 and melanoma.