Here we report HBV integrations in eight HBV-infected patients, including integration in the vicinity of three previously reported genes, TERT, CCNE1 and MLL4. Aside from individual genes mutated in HCC, we also examine the diverse modes of genomic alteration in this heterogeneous disease, delineating both conventional mutations and virus-associated changes that contribute to liver oncogenesis. Here, TERT is linked to hepatocellular carcinoma.