TPR and cancer: In this study, we confirmed the diverse molecular activity of Antp-TPR in the presence of R11-Hsp70, compared with 17-AAG, toward cancer cells and we found that the combination of Antp-TPR with R11-Hsp70 induced neither up-regulation of Hsp90, Hsp70, Hsp27, or Hop, nor an increase in GSH concentration in breast cancer cells (Figure 3, Figure 4, and Figure 5A).