Since Antp-TPR caused the rapid cancer cell-killing compared with 17-AAG, and 17-AAG induced the up-regulation of Hsp proteins quickly as reported previously [14], and neither Antp-TPR alone nor Antp-TPR with R11-Hsp70 induced the up-regulation of Hsp proteins as mentioned above, it is suggested that the disruption of protein homeostasis without the up-regulation of Hsp proteins through inhibition of Hsp90 or Hsp90 and Hsp70 function by Antp-TPR with or without R11-Hsp70 might affect the GSH concentration in cancer cells. The gene discussed is TPR; the disease is cancer.