EZH2 expression was significantly related to increased tumor cell proliferation, as assessed by Ki-67 expression with a cutoff value of 37% (p <0.001).High EZH2 expression was correlated closely with low differentiation (p = 0.029), high CEA level (p = 0.041), T4 status (p = 0.011) and Node metastasis (p =0.045). The gene discussed is EZH2; the disease is neoplasm.