EZH2 and neoplasm: It seemed that EZH2 low expression could predict the response to nCRT: 30 cases in 53 EZH2 low expression patients achieved good tumor response while 21 cases in 59 EZH2 high expression patients did (p = 0.026); 34 cases in 53 EZH2 low expression patients achieved down-staging while 25 cases in 59 high expression patients did (p = 0.021).