By multivariate stepwise logistic regression analysis, we found low expression of EZH2 showed significant correlation with good tumor regression (OR = 2.684; 95% CI 1.147-6.280, p = 0.023) and down staging (OR = 2.476; 95% CI 1.107-5.537, p = 0.027). Here, EZH2 is linked to neoplasm.