Supporting these findings, it has been reported that four- to five-year old children in Uganda with the highest incidence of malaria in the prior year of the study (> = seven episodes/year, n = 20) exhibited a transient drop in frequencies of IgD+CD27+IgM+B cells at the time of acute malaria, not seen in subjects with a lower incidence [92]. The gene discussed is CD40LG; the disease is malaria.