Notably, these null results for anxiety in the KO mice contrast with numerous studies which have reported anxiolytic effects with mGlu2/3 agonists (Dunayevich et al., 2008, Grillon et al., 2003, Helton et al., 1998, Linden et al., 2005, Schoepp et al., 2003, Shekhar and Keim, 2000). The gene discussed is GRM2; the disease is Anxiety.