GRM3 and Anxiety: GRM3−/− mice did demonstrate shorter latencies to enter the open arms in the elevated plus maze (U = 58; p < 0.05; Table 3), and to approach (U = 65.5; p < 0.05) and eat (U = 39.0; p < 0.01) the novel food in the second neophagia test compared to controls (Table 6), potentially consistent with reduced anxiety in these animals.