HMGA2 and polycystic ovary syndrome: Interestingly, a recent genome-wide association study (GWAS) on the etiology of PCOS [69] identified one SNP in the intronic region of the high mobility group AT-hook 2 (HMGA2) gene and one SNP in the intergenic region near the Ras-related protein Rab-5B (RAB5B) gene.