In addition to the independent role of HOTAIR in OS, two other studies respectively found that HOTAIR was an independent factor for cancer metastasis but not for the recurrence of cancer (pooled HR 3.90, 95%CI: 2.25–6.74; pooled HR 1.28, 95%CI: 0.18–9.29) (Table 3) (Figure 3). Here, HOTAIR is linked to cancer.