In terms of gastric cancer, HOTAIR expression was found to be significantly associated with lymph node metastasis (present vs. absent: OR 4.47, 95%CI:1.88–10.63) and vessel invasion (positive vs. negative: OR 2.88, 95%CI: 1.38–6.04) while TNM stage (III/IV vs. I/II: OR 1.94, 95%CI:0.65–5.85) and depth of invasion (T3/4 vs. T1/2: OR 1.32, 95%CI:0.63–2.77) tended to have relatively weaker correlations with HOTAIR expression. This evidence concerns the gene HOTAIR and gastric cancer.