Combining these HRs suggests that HOTAIR expression might be an independent prognostic factor for cancer patients (pooled HR 2.26, 95%CI: 1.62–3.15) (Figure 3), but a significant heterogeneity was detected among studies (χ2 = 27.25, df = 11, p = 0.004, I2 = 59.6%). Here, HOTAIR is linked to cancer.