Glycogen synthase kinase 3 (GSK3), a constitutive multi-functional serine threonine kinase, was involved in diversely physiological pathways ranging from insulin signaling pathways which associated with the disease of type 2 diabetes mellitus (T2DM) and Wnt signaling pathways which related to oncogenesis [4]–[7]. This evidence concerns the gene MARK2 and type 2 diabetes mellitus.