PTGS2 and malignant colon neoplasm: Down-regulation of AP-1 transcriptional binding by [6]-gingerol directly implies to its therapeutic potential against colon cancer, as AP-1 is known to be the transcription factor responsible for transcription of effectors like COX-2, MMPs and VEGF, which are responsible for invasiveness, metastasis and angiogenesis in colon cancer tumors [46], [54].