Another recent study on inhibitory effect on [6]-gingerol on LoVo cells describes down-regulation of cell cycle regulators Cyclin A, B1 and CDK1 along with the increase in the generation of intracellular reactive oxygen species (ROS) as the mechanism of action [15].The present study identifies a totally different mechanism of action for [6]-gingerol in colon cancer cells. Here, CCNA2 is linked to colonic neoplasm.