NF-kappaB is also known to facilitate angiogenesis, invasion and metastasis in colon cancer tumor cells by up-regulating vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), interleukine (IL)-6 and matrix metalloproteinases (MMPs) [52], [53]. Here, PTGS2 is linked to malignant colon neoplasm.