When we first examined the effect of the GRS including all T2D susceptibility variants (GRS_Total) on the risk of early redemption of a glucose lowering drug prescription in a multifactor-adjusted model neither time to 1st drug nor time to 1st insulin were affected by the GRS, 1st-drug-HRintensive [95% C.I.] = 1.01 [0.99–1.04], p = 0.35 and 1st-drug-HRconventional = 0.98 [0.95–1.02], p = 0.34 respectively and 1st-insulin-HRintensive [95% C.I.] = 1.03 [0.97–1.09], p = 0.37 and 1st-insulin-HRconventional = 0.88 [0.79–0.98], p = 0.02 respectively (table 2). This evidence concerns the gene INS and type 2 diabetes mellitus.