Examples of adipokine effects comprise the modulating influence of adiponectin, visfatin, nesfatin, vaspin, and chemerin on obesity-related vascular complications [58, 59] as well as those of adiponectin, leptin, resistin, visfatin, and chemerin on inflammatory and destructive processes [60–63] and cardiovascular risk [64] in RA. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.