Its anti-inflammatory activity in acne could also be related to a decrease in tumor necrosis factor- (TNF-) α and IL-6 production and modulation of the expression of integrins, mainly intracellular adhesion molecule- (ICAM-) 1 and leucocyte function associated antigen- (LFA-) 3 [21, 30]. The gene discussed is IL6; the disease is acne.