EGFR and large cell carcinoma: EGFR mutations (non-squamous histology)1. ~15% in Caucasians2. ~40% in Asians3. ~75–80% in never-smoker AsiansEGFR mutations (squamous histology)1. ~5%EGFR over-expression1. 39% in adenocarcinoma2. 58% in squamous cell carcinoma3. 38% in large-cell carcinoma