NFKB1 and obesity due to melanocortin 4 receptor deficiency: In a more recent series of studies, salicylates were found to be potentially useful for the treatment of high-fat diet-induced insulin resistance in diabetes in human subjects (70), yet results are mixed (71), and blockade of NF-κB is very downstream in the VAT inflammatory pathway in obesity, so inflammatory cell numbers are not typically affected (13).