PPARGC1A and sarcopenia: Gouspillou et al. (2013) hypothesized that the denervation and innervation cycle observed with aging is under the control of PGC-1α expression and proposed that the aging-related decline in PGC-1α may be a central mechanism promoting instability of the NMJ and consequently aging-related alterations of myofiber innervation in sarcopenia.