Furthermore, our results in Figures 3A,B also demonstrate that the most impact on the proliferative capacities of both the CD8+ and CD4+ T cells in PD-L1-/- mice, after stroke, was when neutralizing Abs to CD80 + CTLA-4 and PD-1 + PD-L2 were used. The gene discussed is PDCD1; the disease is Stroke.