Its protective role as an immune mediator emerged as early as in the liver stage [126, 188–193]. In vitro study of human recombinant IFN-γ treatment on P. berghei sporozoites-infected murine hepatocytes [190] or human hepatoma cells [189] identified an inhibitory effect of IFN-γ on parasite multiplication. Here, IFNG is linked to hepatocellular carcinoma.