Thus, in this study, we aimed to determine the role of P2Y2R, which is activated equipotently by ATP and UTP, in cancer cell metastasis, and we found that P2Y2R activation by ATP or UTP increased MDA-MB-231 cell proliferation and AM-mediated migration and also stimulated AM expression in ECs, resulting in increased adhesion of MDA-MB-231 to ECs. Here, P2RY2 is linked to cancer.