However, the role of P2X7R in cancer is controversial; some studies have reported that P2X7R activation by ATP produces a trophic, growth-promoting effect [8], but according to the review by White and Burnstock [41], P2X7R may also decrease the number of cancer cells in contrast to P2Y2R. In this respect, investigating the role of P2Y2R and its potential involvement in cancer metastasis is important for developing effective anticancer strategies. The gene discussed is P2RY2; the disease is cancer.