Although we cannot exclude biopsy sampling bias, FISH on the prostatectomy sample confirmed the presence of the androgen-driven TMPRSS2-ERG rearrangement, suggesting an adenocarcinoma origin for the NEPC component within tumor T20 and the potential that this therapy resistant tumor was driven (at least in part) by NHT treatment (Figure 1; Additional file 2: Figure S2; Additional file 3: Text S1) [14–17]. This evidence concerns the gene TMPRSS2 and adenocarcinoma.