ERG and neoplasm: It is of note that the NHT tumor (T20) with a significant NEPC component was positive for both ERG and ETV1 rearrangements (by RNA sequencing and PCR validation); raising the possibility of multi-focal ‘collision’ cancers where only the ERG rearranged cells ‘transdifferentiated’ into NEPC (discussed further in Additional file 3: Text S1).