In 18 tumors fusion gene events caused disruption to known or putative tumor suppressor genes, including genes associated with TP53 apoptosis (for example, TP53 in four tumors; PPP1R13B), MAPK p38 apoptosis (for example, MAP3K5), cell cycle progression (for example, RB1, CCND3), DNA damage response (for example, MRE11A), and DNA architecture (for example, PDS5A) (Figure 3A; Additional file 1: Table S9). This evidence concerns the gene RB1 and neoplasm.