Mutant huntingtin protein can be cleared by macroautophagy but impairs its own clearance through impaired cargo recognition.48 Enhancing autophagy through mammalian target of rapamycin (mTOR) inhibition by rapamycin improved phenotypes in fly and mouse models of HD,49 and a number of agents have shown similar effects in model systems,50 and upregulation of autophagy to clear mHTT is an important potential therapeutic strategy. Here, HTT is linked to Huntington disease.