HTT and Huntington disease: One striking recent report linked to post-translational modification concerns gangliosides—CNS-abundant glycosphingolipids with roles in membrane functioning and cell signaling that have been shown to be deficient in HD models.40 Chronic intraventricular infusion of ganglioside GM1 in YAC128 mice restored normal motor function and expression of the striatal marker DARPP32 and increased phosphorylation of HTT at serines 13 and 16.41 The mechanism of this intriguing result is unclear: It requires replication and further mechanistic study as a possible therapeutic avenue.