According to the least squares method of analysis, when the ND score was above 35%, the risk that the EGFR expression score was IHC 2+ rather than IHC 1+ was 8.19 times higher for 13th JGCA pStage II/III gastric cancers treated with S-1 (P = 0.0053) (Table3). The gene discussed is EGFR; the disease is gastric cancer.