For example, at the time of our research the Urological Society of Australia and New Zealand [40] has recommended that asymptomatic men aged 55-69 years should be offered a prostate-specific antigen (PSA) test and digital rectal examination (DRE) after the patients have been advised on the risks and benefits of PSA screening, while in contrast, the Ministry of Health (The National Screening Advisory Committee) has not supported population-based screening for prostate cancer [7]. Here, KLK3 is linked to Familial prostate cancer.