The univariate logistical and multivarite Cox regression models adjusted for other factors indicate that the duration time (years), splenomegaly, serum ALB and rs10118570 were recorded to be significantly different between advanced fibrosis group and mild fibrosis group (all P<0.05) in the discovery cohort (Figure 5A) and the replicative cohort (Figure 5B). Here, ALB is linked to Splenomegaly.