In the human umbilical vein endothelial cell line, EA.hy926, the increased expression of various Kruppel-like transcription factors, which have tumor-suppressing functions, and the modulation of cell cycle related genes (such as CCNA2, CCNE2, CCNB1 and CCNB2) provides evidence for an anti-cancer effect of atorvastatin [46]. This evidence concerns the gene CCNE2 and neoplasm.