Next, to confirm whether sMEK1 plus paclitaxel induced apoptotic cell death via the Akt/Rheb/mTORC1-S6K/4E-BP-dependent signaling pathways in carcinoma cells in vivo, ovarian-tumor-containing mice were sacrificed after each treatment and tumor tissues were subjected to Western blotting. This evidence concerns the gene RHEB and carcinoma.