With the abundance of helicase and UPS associated genes in our glioma signatures, another cancer promoting scenario may be introduced through changes to gene-products that compose spliceosome complexes (snRNA, snRNP, or snoRNP); through these genetic modifications, alternatively spliced RNAs may support spliceosome-associated proteins differently, which may further modify mature RNAs. Here, HMBS is linked to glioma.