When patients from a breast cancer cohort were categorized into SPHK1-low and high groups based on median expression of SPHK1 (7.34 for OS, and 7.32 for PFS) (Supplementary Data Fig. 2A), patient survival analysis revealed an inverse correlation between SPHK1 expression level and the overall (OS) and progression-free survival (PFS) of breast cancer patients (p=0.0401 and p=0.0052 respectively) (Fig. 1D). Here, SPHK1 is linked to breast cancer.