MRC1 and colorectal carcinoma: When we previously investigated the prognostic power of combined MMR and BRAFV600E IHC in a group of 1426 CRC from 2004 to 2009 [3], univariate analysis demonstrated that MMRp/BRAFV600E CRCs had a statistically significantly worse outcome compared to the other phenotypes (hazard ratio of 1.79 (95%CI = 1.24–2.60), (p)<0.01).