NGFR and Alzheimer disease: Since levels of p75NTR have been shown to increase in AD patients [24], [25] and mouse models [26], [27] with late-stage pathology and p75NTR is the target of LM11A-31, we determined whether p75NTR immunostaining was increased in the basal forebrain of APPL/S mice at the ages involved in this study, and if levels were affected by the ligand, which could suggest target engagement.