THY1 and Alzheimer disease: Therefore, this study examined whether LM11A-31 could arrest or reverse the degeneration of cholinergic neurites in two well characterized AD models, Thy-1 hAPPLond/Swe (APPL/S) and Tg2576 mice, with treatment beginning in mid- to late stages of disease progression characterized by the presence of abundant amyloid deposits, well established BFCN degeneration, and memory deficits apparent in multiple testing paradigms [14], [16], [19], [20], [21].